diff --git a/Lib/concurrent/interpreters/_queues.py b/Lib/concurrent/interpreters/_queues.py
index ee159d7de63827..cb60be18b39e86 100644
--- a/Lib/concurrent/interpreters/_queues.py
+++ b/Lib/concurrent/interpreters/_queues.py
@@ -11,7 +11,7 @@
     QueueError, QueueNotFoundError,
 )
 from ._crossinterp import (
-    UNBOUND_ERROR, UNBOUND_REMOVE,
+    UNBOUND, UNBOUND_ERROR, UNBOUND_REMOVE,
 )
 
 __all__ = [
@@ -46,9 +46,6 @@ class ItemInterpreterDestroyed(QueueError,
 _PICKLED = 1
 
 
-UNBOUND = _crossinterp.UnboundItem.singleton('queue', __name__)
-
-
 def _serialize_unbound(unbound):
     if unbound is UNBOUND:
         unbound = _crossinterp.UNBOUND
diff --git a/Lib/test/test_concurrent_futures/test_interpreter_pool.py b/Lib/test/test_concurrent_futures/test_interpreter_pool.py
index 7241fcc4b1e74d..5c84a42d74fee4 100644
--- a/Lib/test/test_concurrent_futures/test_interpreter_pool.py
+++ b/Lib/test/test_concurrent_futures/test_interpreter_pool.py
@@ -427,6 +427,8 @@ def run(taskid, ready, blocker):
                         ready.get(timeout=1)  # blocking
                     except interpreters.QueueEmpty:
                         pass
+                    except queues.QueueEmpty:
+                        pass
                     else:
                         done += 1
                 pending -= done
diff --git a/Lib/test/test_interpreters/test_queues.py b/Lib/test/test_interpreters/test_queues.py
index 77334aea3836b9..c5e78235c855df 100644
--- a/Lib/test/test_interpreters/test_queues.py
+++ b/Lib/test/test_interpreters/test_queues.py
@@ -8,6 +8,7 @@
 # Raise SkipTest if subinterpreters not supported.
 _queues = import_helper.import_module('_interpqueues')
 from concurrent import interpreters
+from concurrent.futures import InterpreterPoolExecutor
 from concurrent.interpreters import _queues as queues, _crossinterp
 from .utils import _run_output, TestBase as _TestBase
 
@@ -93,6 +94,14 @@ def test_bind_release(self):
             with self.assertRaises(queues.QueueError):
                 _queues.release(qid)
 
+    def test_interpreter_pool_executor_after_reload(self):
+        # Regression test for gh-142414 (KeyError in serialize_unbound).
+        importlib.reload(queues)
+        code = "import struct"
+        with InterpreterPoolExecutor(max_workers=1) as executor:
+            results = executor.map(exec, [code] * 1)
+            self.assertEqual(list(results), [None] * 1)
+
 
 class QueueTests(TestBase):
 
diff --git a/Misc/NEWS.d/next/Library/2025-12-10-15-27-58.gh-issue-142414.zTHgP-.rst b/Misc/NEWS.d/next/Library/2025-12-10-15-27-58.gh-issue-142414.zTHgP-.rst
new file mode 100644
index 00000000000000..147c6e4b5dee2c
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2025-12-10-15-27-58.gh-issue-142414.zTHgP-.rst
@@ -0,0 +1 @@
+Fix spurious :exc:`KeyError` when :mod:`concurrent.interpreters` is reloaded after import.