diff --git a/lib/pythonx.ex b/lib/pythonx.ex
index 4600022..a2dc288 100644
--- a/lib/pythonx.ex
+++ b/lib/pythonx.ex
@@ -54,10 +54,19 @@ defmodule Pythonx do
     * `:uv_version` - select the version of the uv package manager to use.
       Defaults to `#{inspect(Pythonx.Uv.default_uv_version())}`.
 
+    * `:native_tls` - if true, uses the system's native TLS implementation instead
+      of vendored rustls. This is useful in corporate environments where the system
+      certificate store must be used. Defaults to `false`.
+
   '''
   @spec uv_init(String.t(), keyword()) :: :ok
   def uv_init(pyproject_toml, opts \\ []) when is_binary(pyproject_toml) and is_list(opts) do
-    opts = Keyword.validate!(opts, force: false, uv_version: Pythonx.Uv.default_uv_version())
+    opts =
+      Keyword.validate!(opts,
+        force: false,
+        uv_version: Pythonx.Uv.default_uv_version(),
+        native_tls: false
+      )
 
     Pythonx.Uv.fetch(pyproject_toml, false, opts)
     install_paths = Pythonx.Uv.init(pyproject_toml, false, Keyword.take(opts, [:uv_version]))
diff --git a/lib/pythonx/uv.ex b/lib/pythonx/uv.ex
index 78312b9..8fb039e 100644
--- a/lib/pythonx/uv.ex
+++ b/lib/pythonx/uv.ex
@@ -10,7 +10,8 @@ defmodule Pythonx.Uv do
   """
   @spec fetch(String.t(), boolean(), keyword()) :: :ok
   def fetch(pyproject_toml, priv?, opts \\ []) do
-    opts = Keyword.validate!(opts, force: false, uv_version: default_uv_version())
+    opts =
+      Keyword.validate!(opts, force: false, uv_version: default_uv_version(), native_tls: false)
 
     project_dir = project_dir(pyproject_toml, priv?, opts[:uv_version])
     python_install_dir = python_install_dir(priv?, opts[:uv_version])
@@ -28,7 +29,10 @@ defmodule Pythonx.Uv do
       File.write!(Path.join(project_dir, "pyproject.toml"), pyproject_toml)
 
       # We always use uv-managed Python, so the paths are predictable.
-      if run!(["sync", "--managed-python", "--no-config"],
+      base_args = ["sync", "--managed-python", "--no-config"]
+      uv_args = if opts[:native_tls], do: base_args ++ ["--native-tls"], else: base_args
+
+      if run!(uv_args,
            cd: project_dir,
            env: %{"UV_PYTHON_INSTALL_DIR" => python_install_dir},
            uv_version: opts[:uv_version]